If any of you guys happen to have a Sky Blue and an EGDM, I found this combination to be a great distortion.
Setting
Sky Blue
V = 9 o'clock
Z = 9 o'clock
Texture = 9 o'clock
Distortion = 11 o'clock
EGDM
V = 10 o'clock
Voice = 11 o'clock
Distortion = Noon
With guitar on bridge pickup, this delivers an aggressive full-bodied modern-ish distortion -- arena rock guitar god type tone.