I am not a gamer at all, but one of my co-workers had a party a couple weeks ago and had just gotten a Wii with Guitar Hero III. I was skeptical like every guitar player would be, but once the music came on I wanted to try. I have to say, it was blast! Admittedly, it's not apples to apples with playing a real guitar, but is was pretty fun and does require some of the same basic timing and dexterity.
I've tried it. I actually found that being a real guitarist hampered my ability to play the game and use their fingerings ... especially when I really know how to play a lot of the songs that are on there. Kids who don't know the first thing about real guitar kicked my ass on the game.
Guitars:: Les Pauls, V with P-90's and humbuckers, strats,tele duo-jet and expanding; pick ups mostly Lundgren or BJF/ Lundgren Danelectro Barython
amps: MP CS-40, MP101, Hiwatt Custom 200, Hiwatt Custom 100, VOX AC15 Fender Blues De Ville, Fender Super Reverb, Marshall 5150 through various speakers