Donner gave me some great advice recently --- to move my tuner (Boss - buffer) to the back of the line and put my fuzz up front --- it blows me away how much more alive my fuzz is now! I have a D*A*M 1966 that I felt never quite lived up to the hype and now it is a whole new animal. I actually feel somewhat stupid for not having put more effort into trying different pedal placements.
Any revelations you guys have discovered along the way?