I use it as the last pedal except for the rare times I run the RRB after it. It seems much of the time I run it with a slight boost and the Bass and Treble flat unless I am playing really quiet or loud and I add Treble or Bass.
Mine is an early one and it seems to be a bit dirtier, in a great way, than some of the others I have tried. Mine is on most of the time as is my PGC, but I do have a buffer in my SBEQ for the times I have it off. The buffer makes fuzzes act strangely so I have to have it on if I need fuzz.
If I had unlimited amounts of money I could see trading out the PGC (pedal order listed below) for a second SBEQ and run it in the same place the PGC is now. I really do not add much compression and now that I think about it it would be a better sweetener than the PGC.