Yeah really with a good distortion and an EQ before and after you could make about any drive sound you could think of..............
And since you mentioned Gilmour (a personal top 5) he and Eric Johnson are where I got t hat idea......
I went to see Eric johnson at a place where I could walk right up to the stage and see his pedalboard ( and I even touched his fuzzy thingy
)
and I noticed that the Tube Driver that everyone talked about was set oddly, the treble a nd bass controls were most of the way down and the gain level was even down a bit, which made no sense ......
until I went home and put t he same setting on my SBEQ and Tube Driver and played my Strat up above the 10th fret and there was the sound --- its reshaping the strat bridge pickup and ten when you run that into a screaming amp ---- ding! Hes using it as a tube EQ.
And I get closest to Gilmours singing tones with a Rat and a EQ instead of a muff ...............
with your set up I would use the Parametric as the mid bumping lead boosts and the Graphics as over all shapers.................
And one very important trick I learned from BJ about EQ is that often the best way to get clearer treble is not to increase treble, but to reduce the correct bass frequencies.... removing the mud is often the best way to increase clarity.